Salvador Naranjo

 

Contact: snaranjo@clinic.cat

Academic Role: Postdoctoral Researcher

Biography: Salvador Naranjo (Sevilla, 1977) earned his Bachelor’s of Science degree in Biochemistry from the Autonomous University of Madrid in 2000 and his PhD degree in Biochemistry and Molecular Biology from the Autonomous University of Madrid in 2006. He conducted predoctoral research at the Immunology Department of the Hospital de la Princesa in Madrid (2000-2006). He then performed postdoctoral research at the Laboratory of Experimental Carcinogenesis of the Center for Cancer Research, National Cancer Institute (Bethesda, Maryland, USA) (2006-2009), at the Laboratory of Cancer Prevention of the Center for Cancer Research, National Cancer Institute (Bethesda, Maryland, USA) (2009-2011), at the Department of Pathology of the Sol Godman Pancreatic Cancer Research Center in the John Hopkins School of Medicine (Baltimore, Maryland, USA) (2011-2014), and at the Department of Pathology of the David M Rubenstein Center for Pancreatic Cancer Research in the Memorial Sloan Kettering Cancer Center (New York, NY, USA) (2014-2015). He has also earned the professional Certificate in Introduction to mAdb (2006), the Certificate in Analysis of microarray data using the mAdb system (2006), the Certificate in Statistical analysis of microarray data (2007), the Certificate in Clustering, dendrograms and heat maps (2007), the Certificate in Ingenuity Pathways Analysis (2007), and the Certificate in GeneSpring GX for gene expression (2008), all of them from the Center for Information Technology (CIT) of the National Institutes of Health (NIH). He also earned the Certificate in Training on Experimental Animal Use and Design of Research Projects of the University of Barcelona (2016), and participates in the oficial IDIBAPS Training Programme for Pre and Postdoctoral Researchers (from 2016). In October 2018, Salva co-organized and co-presented the Workshop in Vascular Biology Techniques during the European Club for Liver Cell Biology meeting (Bonn, Germany). He also participated as a Faculty Member in the Basic School of Hepatology of the European Association for the Study of Liver (Barcelona, October 2018). Salva joined the Mercedes Fernandez Lab in November 2015 with a Postdoctoral Research Contract from the Spanish Association Against Cancer.

Publications

Pathogenesis of portal hypertension: Extrahepatic mechanisms

Fernandez M, Mejias M, Garcia-Pras E, Gallego J, Pell N, Ramirez M, Naranjo-Suarez S, Barrachina-Catala A

Corresponding author: Mercedes Fernandez

Current Hepatology Reports (2016) 15:199-207

Invited Review

The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways.

Tsuji PA, Carlson BA, Yoo MH, Naranjo-Suarez S, Xu XM, He Y, Asaki E, Seifried HE, Reinhold WC, Davis CD, Gladyshev VN, Hatfield DL.

PLoS One (2015) 10: e0124487

Functional p38 MAPK identified by biomarker profiling of pancreatic cancer restrains growth through JNK inhibition and independently correlates with survival.

Zhong Y, Naito Y, Cope L, Naranjo-Suarez S, Saunders T, Hong SM, Goggins M, Herman JM, Wolfgang CL, Iacobuzio-Donahue CA.

Clinical Cancer Research (2014) 20: 6200-6211

Regulation of HIF-1α activity by overexpression of thioredoxin is independent of thioredoxin status.

Naranjo-Suarez S, Carlson BA, Tobe R, Yoo MH, Tsuji PA, Gladyshev VN, Hatfield DL.

Molecules and Cells (2013) 36: 151-157

High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin.

Tobe R, Naranjo-Suarez S, Everley RA, Carlson BA, Turanov AA, Tsuji PA, Yoo MH, Gygi SP, Gladyshev VN, Hatfield DL.

Journal of Biological Chemistry (2013) 288: 14709-14715

Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis.

Carlson BA, Yoo MH, Tobe R, Mueller C, Naranjo-Suarez S, Hoffmann VJ, Gladyshev VN, Hatfield D.

Carcinogenesis (2012) 33: 1806-1813

HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia.

Naranjo-Suarez S, Carlson BA, Tsuji PA, Yoo MH, Gladyshev VN, Hatfield DL.

PLoS One (2012) 7: e30470

Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation.

Tsuji PA, Carlson BA, Naranjo-Suarez S, Yoo MH, Xu XM, Fomenko D, Gladyshev VN, Hatfield DL, Davis CD.

PLoS One (2012) 7: e50574

Deficiency in the 15 kDa selenoprotein inhibits human colon cancer cell growth.

Tsuji PA, Naranjo-Suarez S, Carlson BA, Tobe R, Yoo MH, Davis CD.

Nutrients (2011) 3: 805-817

Selenoproteins harboring a split personality in both preventing and promoting cancer.

Yoo MH, Carlson BA, Tsuji PA, Tobe R, Naranjo-Suarez S, Lee BJ, Davis CD, Gladyshev VN, Hatfield DL.

In: Selenium: its molecular biology and role in human health (2011) Ed. Springer

Mouse models that target removal or over-expression of the selenocysteine tRNA[Ser]Sec gene to elucidate the role of selenoproteins in health and development.

Carlson BA, Yoo MH, Tsuji PA, Tobe R, Naranjo-Suarez S, Chen F, Feigenbaum L, Tessarollo L, Lee BJ, Gladyshev VN, Hatfield DL.

In: Selenium: its molecular biology and role in human health (2011) Ed. Springer

Inadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau protein defective renal cancer cells.

Feijoo-Cuaresma M, Mendez F, Maqueda A, Esteban MA, Naranjo-Suarez S, Castellanos MC, del Cerro MH, Vazquez SN, Garcia-Pardo A, Landazuri MO, Calzada MJ.

Journal of Biological Chemistry (2008) 283: 24982-24990

Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity.

Cabrero JR, Serrador JM, Barreiro O, Mittelbrunn M, Naranjo-Suarez S, Martin-Cofreces N, Vicente-Manzanares M, Mazitschek R, Bradner JE, Avila J, Valenzuela-Fernandez A, Sanchez-Madrid F.

Molecular Biology of the Cell (2006) 17: 3435-3445

von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms.

Calzada MJ, Esteban MA, Feijoo-Cuaresma M, Castellanos MC, Naranjo-Suarez S, Temes E, Mendez F, Yanez-Mo M, Ohh M, Landazuri MO.

Cancer Research (2006) 66: 1553-1560

Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection.

Valenzuela-Fernandez A, Alvarez S, Gordon-Alonso M, Barrero M, Ursa A, Cabrero JR, Fernandez G, Naranjo-Suarez S, Yanez-Mo M, Serrador JM, Muñoz-Fernandez MA, Sanchez-Madrid F.

Molecular Biology of the Cell (2005) 16: 5445-5454

Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene.

Pescador N, Cuevas Y, Naranjo S, Alcaide M, Villar D, Landazuri MO, Del Peso L.

Biochemical Journal (2005) 390: 189-197

Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas.

Cuevas Y, Hernandez-Alcoceba R, Aragones J, Naranjo-Suarez S, Castellanos MC, Esteban MA, Martin-Puig S, Landazuri MO, del Peso L.

Cancer Research (2003) 63: 6877-6884

Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation.

Naranjo-Suarez S, Castellanos MC, Alvarez-Tejado M, Vara A, Landazuri MO, del Peso L.

Journal of Biological Chemistry (2003) 278: 31895-31901

Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis.

Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, Carrera AC, Landazuri MO, del Peso L.

Journal of Biological Chemistry (2001) 276: 22368-22374


Uso de cookies

Este sitio web utiliza cookies para que usted tenga la mejor experiencia de usuario. Si continúa navegando está dando su consentimiento para la aceptación de las mencionadas cookies y la aceptación de nuestra política de cookies, pinche el enlace para mayor información.plugin cookies

ACEPTAR
Aviso de cookies