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What the results are …


Therapeutic siRNA targeting endothelial KDR decreases portosystemic collateralization in portal hypertension

Gallego J, Garcia-Pras E, Mejias M, Pell N, Schaeper U, Fernandez M

Co-first authors: Javier Gallego and Ester Garcia-Pras

Corresponding author: Mercedes Fernandez

Scientific Reports (2017) doi:10.1038/s41598-017-14818-7  PubMed    Springer Nature SharedIt

Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress

Maillo C, Martin J, Sebastian D, Hernandez-Alvarez M, Garcia-Rocha M, Reina O, Zorzano A, Fernandez M, Mendez R

Co-corresponding authors: Raul Mendez and Mercedes Fernandez

Nature Cell Biology (2017) 19:94-105 PubMed

Comment on this paper: Moore PC & Oakes SA. CPEB4 links the clock and the UPR to protect the liver. Nature Cell Biology (2017);19:79-81. Comment

Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension

Garcia-Pras E, Gallego J, Coch L, Mejias M, Fernandez-Miranda G, Pardal R, Bosch J, Mendez R, Fernandez M

Corresponding author: Mercedes Fernandez

Gut (2017) 66:1306-1320 PubMed

Gastroesophageal varices

Fernandez M, Abraldes JG

Corresponding author: Mercedes Fernandez

In: Liver Pathophysiology: Therapies & Antioxidants (2017) Ed. Muriel P, Academic Press, Elsevier (ISBN: 978-0-12-804274-8)

Invited Review

Sequential functions of CPEB1 and CPEB4 regulate pathologic expression of VEGF and angiogenesis in chronic liver disease

Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R

Co-first authors: Vittorio Calderone and Javier Gallego

Co-corresponding authors: Raul Mendez and Mercedes Fernandez

Gastroenterology (2016) 150:982-997  PubMed

Pathogenesis of portal hypertension: Extrahepatic mechanisms

Fernandez M, Mejias M, Garcia-Pras E, Gallego J, Pell N, Ramirez M, Naranjo-Suarez S, Barrachina-Catala A 

Corresponding author: Mercedes Fernandez

Current Hepatology Reports (2016) doi:10.1007/s11901-016-0306-x   

Invited Review

Molecular pathophysiology of portal hypertension

Fernandez M 

Corresponding author: Mercedes Fernandez

Hepatology (2015) 61:1406-1415 PubMed

Invited Review

Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats

Mejias M, Coch L, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Gut (2015) 64:657-666 PubMed

Editorial devoted to this article: Vespasiani-Gentilucci U, Rombouts K. Boosting pigment epithelial-derived factor: a promising approach for the treatment of early portal hypertension. Gut (2015) 64:523-524 Editorial

Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats

Coch L, Mejias M, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, Mendez R, Fernandez M

Corresponding author: Mercedes Fernandez

Hepatology (2014) 60:633-647 PubMed

Editorial devoted to this article: Chatterjee S. Reversal of vasohibin-driven negative feedback loop of vascular endothelial growth factor/angiogenesis axis promises a novel antifibrotic therapeutic strategy for liver diseases. Hepatology (2014) 60:458-460 Editorial

Hepatology Highlights devoted to this article: Dufour JF. After vasopressin comes vasohibin. Hepatology (2014) 60:447 Highlights

Effects of the combined administration of propranolol plus sorafenib on portal hypertension in cirrhotic rats

D’Amico M, Mejias M, Garcia-Pras E, Abraldes JG, Garcia-Pagan JC, Fernandez M, Bosch J

American Journal of Physiology (2012) 302:G1191-G1198 PubMed

Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension

Mejias M, Garcia-Pras E, Gallego J, Mendez R, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2010) 52:529-539 PubMed

Hepatic endothelial dysfunction and abnormal angiogenesis: New targets in the treatment of portal hypertension

Bosch J, Abraldes JG, Fernandez M, Garcia-Pagan JC

Journal of Hepatology (2010) 53:558-567 PubMed

Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats

Mejias M, Garcia-Pras E, Tiani C, Miquel R, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Hepatology (2009) 49:1245-1256 PubMed

Editorial devoted to this article: Shah VH, Bruix J. Antiangiogenic therapy: not just for cancer anymore? Hepatology (2009) 49:1066-1068 Editorial

Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension

Tiani C, Garcia-Pras E, Mejias M, de Gottardi A, Berzigotti A, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2009) 50:296-305 PubMed

Angiogenesis in liver disease

Fernandez M, Semela D, Bruix J, Colle I, Pinzani M, Bosch J

Journal of Hepatology (2009) 50:604-620 PubMed

As of May/June 2017, this “Highly Cited Paper” received enough citations (265) to place it in the top 1% of its academic field based on a highly cited threshold for the field and publications year. Data from Essential Science Indicators.

Impacto de los inhibidores de la angiogénesis en el tratamiento de la hipertensión portal

Fernandez M

Corresponding author: Mercedes Fernandez

Gastroenterología y Hepatología Continuada (2009) 8:312-317

Invited Review

The somatostatin analogue octreotide inhibits angiogenesis in the earliest, but not in advanced, stages of portal hypertension in rats

Mejias M, Garcia-Pras E, Tiani C, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Cellular and Molecular Medicine (2008) 12: 1690-1699 PubMed

Role of angiogenesis in portal hypertension

Fernandez M, Mejias M, Garcia-Pras E, Bosch J

Corresponding author: Mercedes Fernandez

In: Liver Cirrhosis: From Pathophysiology to Disease Management (2008) Edited by: Bosch J, Burroughs AK, Lammert F, Sauerbruch T, Lebrec D. Springuer, Dordrecht, The Netherlands. Volume 162, pages 112-129

Invited Review

Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats

Fernandez M, Mejias M, Garcia-Pras E, Mendez R, Garcia-Pagan JC, Bosch J

Corresponding author: Mercedes Fernandez

Hepatology (2007) 46:1208-1217 PubMed

This paper received the Award to the Best Publication in Hepatology Research (Year 2007), from the Spanish Association for the Study of the Liver

NAD(P)H oxidase modulates angiogenesis and the development of portosystemic collaterals and splanchnic hyperaemia in portal hypertensive rats

Angermayr B, Fernandez M, Mejias M, Gracia-Sancho J, Garcia-Pagan JC, Bosch J

Corresponding author: Mercedes Fernandez

Gut (2007) 56:560-564 PubMed

Heme oxygenase attenuates oxidative stress and inflammation, and increases VEGF expression in portal hypertensive rats

Angermayr B, Mejias M, Gracia-Sancho J, Garcia-Pagan JC, Bosch J, Fernandez M 

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2006) 44:1033-1039 PubMed

Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats

Fernandez M, Mejias M, Angermayr B, Garcia-Pagan JC, Rodes J, Bosch J 

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2005) 43:98-103 PubMed

Editorial devoted to this article: Moreau R. “VEGF-induced angiogenesis drives collateral circulation in portal hypertension”. J Hepatol 2005;43:6-8 Editorial

Heme oxygenase in portal hypertension and liver disease

Lambrecht RW, Fernandez M, Shan Y, Bonkovsky HL

In: Ascites and Renal Dysfunction in Liver Disease. Pathogenesis, diagnosis and treatment (2005). Edited by: Gines P, Arroyo V, Rodes J, Schrier RW. Blackwell Publishing Ltd, Oxford, United Kingdom. Pg. 125-136

Invited Review

Chronische blockade von häm-oxigenase im portal hypertensiven rattenmodell: Effekte auf angiogenese, oxidativen stress und inflammation 

Angermayr B, Mejias M, Gracia-Sancho J, March S, Peck-Radosavljevic M, Garcia-Pagan JC, Bosch J, Fernandez M

Zeitschrift für Gastroenterologie (2005) doi: 10.1055/s-2005-869607

Oxidativer stress trägt zur hyperdynamen zirkulation im portal-hypertensiven rattenmodell 

Angermayr B, Mejias M, Peck-Radosavljevic M, Garcia-Pagan JC, Rodes J, Bosch J, Fernandez M

Zeitschrift für Gastroenterologie (2005) 43;05

Anti-VEGF receptor-2 monoclonal antibody prevents portal-systemic collateral vessel formation in portal hypertensive mice

Fernandez M, Vizzutti F, Garcia-Pagan JC, Rodes J, Bosch J

Corresponding author: Mercedes Fernandez

Gastroenterology (2004) 126:886-894 PubMed

Vascular endothelial growth factor increases heme oxygenase-1 expression in the chicken embryo chorioallantoic membrane 

Fernandez M, Bonkovsky HL

Corresponding author: Mercedes Fernandez

British Journal of Pharmacology (2003) 139:634-640 PubMed

Increased heme oxygenase activity in splanchnic organs from portal hypertensive rats: Role in modulating mesenteric vascular reactivity 

Fernandez M, Lambrecht RW, Bonkovsky HL

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2001) 34:812-817 PubMed

Editorial devoted to this article: Moreau R. Heme oxygenase: protective enzyme or portal hypertensive molecule?. Journal of Hepatology (2001) 34:936-939 Editorial

Increased heme oxygenase-1 gene expression in liver cells and splanchnic organs from portal hypertensive rats

Fernandez M, Bonkovsky HL

Corresponding author: Mercedes Fernandez

Hepatology (1999) 29:1672-1679 PubMed

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