03 Mar Posttranscriptional Reprogramming of Metabolism as a Driver of Hepatic Stellate Cell Activation in Liver Fibrosis. Published in Gastroenterology 2020
By Marc Mejias, Javier Gallego, Salvador Naranjo-Suarez, Marta Ramirez, Nuria Pell, Anna Manzano, Clara Suñer, Ramon Bartrons, Raul Mendez, Mercedes Fernandez. Corresponding author: M Fernandez.
CPEB4 increases expression of PFKFB3 to induce glycolysis and activate mouse and human hepatic stellate cells, promoting liver fibrosis. Gastroenterology 2020; S0016-5085(20)30328-0 (doi:10.1053/j.gastro.2020.03.008).
This study demonstrates that CPEB4-driven PFKFB3-mediated glycolytic reprogramming is a central player in the activation and fibrogenic potential of hepatic stellate cells, and a novel druggable target that opens new therapeutic antifibrosis opportunities.