Marc Mejias

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Contact: mmejias@clinic.cat

Academic Role: Postdoctoral Researcher

Biography: Marc Mejias (Barcelona, 1978) earned his Bachelor’s of Science degree in Biology from the University of Barcelona in 2003 and his Ph.D. degree in Biology from the University of Barcelona in 2010. He was awarded with a Predoctoral Fellowship from the Spanish Ministry of Science. Furthermore, his doctoral thesis entitled “Role of angiogenesis in the pathophysiology of portal hypertension”, directed by Mercedes Fernandez, received the Excellent Cum Laude qualification and was awarded with the University of Barcelona Extraordinary Doctorate Prize for the academic year 2009/2010. He has also earned the professional Certificate in Training on Experimental Animal Use and Design of Research Projects of the University of Barcelona (2003), the Certificate in Introduction to Flow Cytometry from IDIBAPS (2016), and participates in the oficial IDIBAPS Training Programme for Pre and Postdoctoral Researchers (from 2016). He also participated as a Faculty Member in the Basic School of Hepatology of the European Association for the Study of Liver (Barcelona, October 2018). Marc joined the Mercedes Fernandez Lab in June 2003.

Publications

Pericytes in the gut

Ramirez M, Pell N, Mejias M, Fernandez M

Co-first authors: Marta Ramirez and Nuria Pell

Corresponding author: Mercedes Fernandez

Advances in Experimental Medicine and Biology, “Biology of Pericytes: Development, Homeostasis and Disease”. Springer (ISSN:0065-2598)(in press)

Therapeutic siRNA targeting endothelial KDR decreases portosystemic collateralization in portal hypertension

Gallego J, Garcia-Pras E, Mejias M, Pell N, Schaeper U, Fernandez M

Co-first authors: Javier Gallego and Ester Garcia-Pras

Corresponding author: Mercedes Fernandez

Scientific Reports (2017) 7:14791-14806  PubMed    Springer Nature SharedIt

Gene therapy with endothelial-specific liposomal short interfering siRNA targeting kinase insert domain receptor inhibits portosystemic collateralization in portal hypertension

Gallego J, Garcia-Pras E, Mejias M, Pell N, Schaeper U, Fernandez M

Corresponding author: Mercedes Fernandez

Hepatology (2017); 66(1) (Suppl.): 141A

This abstract has been presented in Parallel Session at the Liver Meeting of the American Association for the Study of Liver Disease (AASLD) (Washington DC, 2017). The speaker and coauthor, Nuria Pell, has been awarded with the 2017 Basic Science Young Investigator Travel Award from AASLD, which recognizes outstanding young basic science researchers working on liver disease. 

Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension

Garcia-Pras E, Gallego J, Coch L, Mejias M, Fernandez-Miranda G, Pardal R, Bosch J, Mendez R, Fernandez M

Corresponding author: Mercedes Fernandez

Gut (2017) 66:1306-1320

Sequential functions of CPEB1 and CPEB4 regulate pathologic expression of VEGF and angiogenesis in chronic liver disease

Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R

Co-first authors: Vittorio Calderone and Javier Gallego

Co-corresponding authors: Raul Mendez and Mercedes Fernandez

Gastroenterology (2016) 150:982-997

Pathogenesis of portal hypertension: Extrahepatic mechanisms

Fernandez M, Mejias M, Garcia-Pras E, Gallego J, Pell N, Ramirez M, Naranjo-Suarez S, Barrachina-Catala A

Corresponding author: Mercedes Fernandez

Current Hepatology Reports (2016) 15:199-207

Invited Review

Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats

Mejias M, Coch L, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Gut (2015) 64:657-666

Editorial devoted to this article: Vespasiani-Gentilucci U, Rombouts K. Boosting pigment epithelial-derived factor: a promising approach for the treatment of early portal hypertension. Gut (2015) 64:523-524 

Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats

Coch L, Mejias M, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, Mendez R, Fernandez M

Co-first authors: Laura Coch and Marc Mejias

Corresponding author: Mercedes Fernandez

Hepatology (2014) 60:633-647

Editorial devoted to this article: Chatterjee S. Reversal of vasohibin-driven negative feedback loop of vascular endothelial growth factor/angiogenesis axis promises a novel antifibrotic therapeutic strategy for liver diseases. Hepatology (2014) 60:458-460 

Hepatology Highlights devoted to this article: Dufour JF. After vasopressin comes vasohibin. Hepatology (2014) 60:447 

Effects of the combined administration of propranolol plus sorafenib on portal hypertension in cirrhotic rats

D’Amico M, Mejias M, Garcia-Pras E, Abraldes JG, Garcia-Pagan JC, Fernandez M, Bosch J

American Journal of Physiology (2012) 302:G1191-G1198

Role of angiogenesis in the pathophysiology of portal hypertension

Mejias M

Doctoral Thesis – University of Barcelona (2010)

Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension

Mejias M, Garcia-Pras E, Gallego J, Mendez R, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2010) 52:529-539

Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats

Mejias M, Garcia-Pras E, Tiani C, Miquel R, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Hepatology (2009) 49:1245-1256

Editorial devoted to this article: Shah VH, Bruix J. Antiangiogenic therapy: not just for cancer anymore? Hepatology (2009) 49:1066-1068

Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension

Tiani C, Garcia-Pras E, Mejias M, de Gottardi A, Berzigotti A, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2009) 50:296-305

The somatostatin analogue octreotide inhibits angiogenesis in the earliest, but not in advanced, stages of portal hypertension in rats

Mejias M, Garcia-Pras E, Tiani C, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Cellular and Molecular Medicine (2008) 12:1690-1699

Role of angiogenesis in portal hypertension

Fernandez M, Mejias M, Garcia-Pras E, Bosch J

Corresponding author: Mercedes Fernandez

In: Proceedings of the II Falk Gastro-Conference (2008) Ed. Springuer, Dordrecht, The Netherlands, pages 112-129

Invited Review

Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension

Coll M, Genesca J, Raurell I, Rodriguez-Vilarrupla A, Mejias M, Otero T, Oria M, Esteban R, Guardia J, Bosch J, Martell M.

Journal of Hepatology (2008) 49:43-51

Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats

Fernandez M, Mejias M, Garcia-Pras E, Mendez R, Garcia-Pagan JC, Bosch J

Corresponding author: Mercedes Fernandez

Hepatology (2007) 46:1208-1217

This paper received the Award to the Best Publication in Hepatology Research (Year 2007), from the Spanish Association for the Study of the Liver

NAD(P)H oxidase modulates angiogenesis and the development of portosystemic collaterals and splanchnic hyperaemia in portal hypertensive rats

Angermayr B, Fernandez M, Mejias M, Gracia-Sancho J, Garcia-Pagan JC, Bosch J

Corresponding author: Mercedes Fernandez

Gut (2007) 56:560-564

Heme oxygenase attenuates oxidative stress and inflammation, and increases VEGF expression in portal hypertensive rats

Angermayr B, Mejias M, Gracia-Sancho J, Garcia-Pagan JC, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2006) 44:1033-1039

Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats

Fernandez M, Mejias M, Angermayr B, Garcia-Pagan JC, Rodes J, Bosch J

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2005) 43:98-103

Editorial devoted to this article: Moreau R. “VEGF-induced angiogenesis drives collateral circulation in portal hypertension”. Journal of Hepatology (2005) 43:6-8

Chronische blockade von häm-oxigenase im portal hypertensiven rattenmodell: Effekte auf angiogenese, oxidativen stress und inflammation 

Angermayr B, Mejias M, Gracia-Sancho J, March S, Peck-Radosavljevic M, Garcia-Pagan JC, Bosch J, Fernandez M

Zeitschrift für Gastroenterologie (2005) doi: 10.1055/s-2005-869607

Oxidativer stress trägt zur hyperdynamen zirkulation im portal-hypertensiven rattenmodell 

Angermayr B, Mejias M, Peck-Radosavljevic M, Garcia-Pagan JC, Rodes J, Bosch J, Fernandez M

Zeitschrift für Gastroenterologie (2005) 43;05

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