Javier Gallego

 

Contact: javier.gallego@ciberehd.org

Academic Role: Postdoctoral Researcher

Biography: Javier Gallego (Sevilla, 1976) earned his Bachelor’s of Science degree in Biology from the University of Sevilla in 2000, his Bachelor’s of Science degree in Biochemistry from the University of Sevilla in 2004, his Master of Science in Liver Disease from the University of Barcelona in 2011, and his PhD degree in Biology and Biochemistry from the University of Barcelona in 2018. He conducted predoctoral research at the Institute of Molecular Biology of Barcelona (IBMB-CSIC) and the Center for Genomic Regulation (CRG, Barcelona). He has also earned the professional Certificate in Clinical Applications for Biological Research Technicians from the University of Seville (2000), the Certificate in Application of the Chemical Characterization Techniques and Pharmaceutical Field from the University of Seville (2001), the Certificate in Training on Experimental Animal Use and Design of Research Projects of the University of Barcelona (2005), the Certificate in Processing and Image Analysis in Advanced Microscopy with ImageJ from the University of Barcelona (2012), and the Certificate in Introduction to Flow Cytometry from IDIBAPS (2016), and participates in the oficial IDIBAPS Training Programme for Pre and Postdoctoral Researchers (from 2016). He also participated as a Faculty Member in the Basic School of Hepatology of the European Association for the Study of Liver (Barcelona, October 2018). Javi joined the Mercedes Fernandez Lab in January 2009.

Publications

Regulatory mechanisms of VEGF-dependent angiogenesis in portal hypertension and cirrhosis

Gallego J

Doctoral Thesis – University of Barcelona (2018)

Ductular reaction cells promote angiogenesis via SLIT2/ROBO1 pathway in chronic liver disease

Coll M, Garcia-Pras E, Aguilar-Bravo B, Gallego J, Blaya D, Vallverdu J, Perea L, Graupera I, Pose E, Lozano J, Bataller R, Gines P, Geng JG, Fernandez M, Sancho-Bru P

Journal of Hepatology (2018); 68: S92

This abstract has been presented as Oral Communication at the Liver Meeting of the European Association for the Study of the Liver (EASL) (Paris, France, 2018).  

Therapeutic siRNA targeting endothelial KDR decreases portosystemic collateralization in portal hypertension

Gallego J, Garcia-Pras E, Mejias M, Pell N, Schaeper U, Fernandez M

Co-first authors: Javier Gallego and Ester Garcia-Pras

Corresponding author: Mercedes Fernandez

Scientific Reports (2017) 7:14791-14806  PubMed    Springer Nature SharedIt

Gene therapy with endothelial-specific liposomal short interfering siRNA targeting kinase insert domain receptor inhibits portosystemic collateralization in portal hypertension

Gallego J, Garcia-Pras E, Mejias M, Pell N, Schaeper U, Fernandez M

Corresponding author: Mercedes Fernandez

Hepatology (2017); 66(1) (Suppl.): 141A

This abstract has been presented in Parallel Session at the Liver Meeting of the American Association for the Study of Liver Disease (AASLD) (Washington DC, 2017). The speaker and coauthor, Nuria Pell, has been awarded with the 2017 Basic Science Young Investigator Travel Award from AASLD, which recognizes outstanding young basic science researchers working on liver disease. 

Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension.

Garcia-Pras E, Gallego J, Coch L, Mejias M, Fernandez-Miranda G, Pardal R, Bosch J, Mendez R, Fernandez M

Corresponding author: Mercedes Fernandez

Gut (2017) 66:1306-1320

Sequential functions of CPEB1 and CPEB4 regulate pathologic expression of VEGF and angiogenesis in chronic liver disease

Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R

Co-first authors: Javier Gallego and Vittorio Calderone

Co-corresponding authors: Raul Mendez and Mercedes Fernandez

Gastroenterology (2016) 150:982-997

Pathogenesis of portal hypertension: Extrahepatic mechanisms

Fernandez M, Mejias M, Garcia-Pras E, Gallego J, Pell N, Ramirez M, Naranjo-Suarez S, Barrachina-Catala A

Corresponding author: Mercedes Fernandez

Current Hepatology Reports (2016) 15:199-207

Invited Review

Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats

Mejias M, Coch L, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Gut (2015) 64:657-666

Editorial devoted to this article: Vespasiani-Gentilucci U, Rombouts K. Boosting pigment epithelial-derived factor: a promising approach for the treatment of early portal hypertension. Gut (2015) 64:523-524 

Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats

Coch L, Mejias M, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, Mendez R, Fernandez M

Corresponding author: Mercedes Fernandez

Hepatology (2014) 60:633-647

Editorial devoted to this article: Chatterjee S. Reversal of vasohibin-driven negative feedback loop of vascular endothelial growth factor/angiogenesis axis promises a novel antifibrotic therapeutic strategy for liver diseases. Hepatology (2014) 60:458-460 

Hepatology Highlights devoted to this article: Dufour JF. After vasopressin comes vasohibin. Hepatology (2014) 60:447 

Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension

Mejias M, Garcia-Pras E, Gallego J, Mendez R, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2010) 52:529-539

Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control

Novoa I, Gallego J, Ferreira PG, Mendez R

Nature Cell Biology (2010) 12:447-456

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