Maria Eugenia Delgado
Contact: medelgado@clinic.cat
Academic Role: Senior Postdoctoral Researcher
Biography: Maria Eugenia Delgado (Esplugues de Llobregat, Barcelona, 1980) earned her Bachelor’s of Science degree in Chemistry from the University of Barcelona (2005), her PhD degree in the Department of Physiology and Medical Physics of the Royal College of Surgeons in Ireland (2014) and her Master in Scientific, Medical and Environmental Communication from the Barcelona School of Management of the Pompeu Fabra University (2017). Her Doctoral Thesis was entitled “Determining the contributions of caspase-2 and caspase-8 to intracellular protease activities during apoptosis initiation”. She obtained the Advanced Studies Diploma from the Complutense University of Madrid (2008) and the Tenure-Eligible Lecturer Report from the AQU Catalunya. She conducted predoctoral research at the Department of Engineering and Agro-Biotechnology of the Polytechnic University of Catalonia (2003-2006), at the Department of Nutrition, Bromatology and Food Technology of the Complutense University of Madrid (2006-2009), and at the Department of Physiology and Medical Physics of the Royal College of Surgeons in Ireland (2009-2013). She then performed postdoctoral research at the Royal College of Surgeons in Ireland (2013-2014) and at the Department of Biology, Biochemical Pharmacology of the University of Konstanz (Germany) (2014-2020). Eugenia has participated (oral presentations) at the EMBO Meeting on Nuclear Receptors and Biological Networks (Kolymbari, Greece, 2018), the 11th European Workshop on Cell Death (European Workshop on Cell Death Organization) (Fiuggi, Italy, 2018), the EMBO Meeting on Cell Death, Inflammation and Cancer (Obergurgl, Austria, 2017), the 9th Swiss Apoptosis Meeting, Bern University (Bern, Switzerland, 2016), the 10th European Workshop on Cell Death (European Workshop on Cell Death Organization) (Fiuggi, Italy, 2016), the 8th Swiss Apoptosis Meeting, Bern University (Bern, Switzerland, 2011), and the 24th Euroconference on apoptosis, European Cell Death Organization (Barcelona, Spain, 2011). She also has extensive teaching experience at the University of Konstanz (2014-2018), the Royal College of Surgeons in Ireland (2013), the Complutense University of Madrid (2006-2008), and the National University of Long-Distance Education (2005-2006). Language skills: Spanish and Catalan (native), English (C2 level), and German (B2 level). Eugenia joined the Mercedes Fernandez Lab in January 2021 after being awarded with a prestigious Postdoctoral Research Contract from the Beatriu de Pinós Program of the Catalan Government. She has earned the Official Certificate in Training on Experimental Animal Use and Design of Research Projects of the University of Barcelona (2021).
Publications
Pharmacological LRH1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis
Schwaderer J, Phan TS, Glöckner A, Delp J, Leist M, Brunner T, Delgado ME* (*corresponding author)
Cell Death & Disease 2020;11:154
Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain
Ripani P, Delp J, Bode K, Delgado ME, Dietrich L, Betzler V, Niu Y, Mayer T, Glöckner A, Leist M, Brunner T
Oncogene 2020;39:2345
The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell functions
Seitz C, Huang J, Geiselhöringer AL, Galbani-Bianchi P, Michalek S, Phan TS, Reinhold C, Dietrich L, Schmidt C, Corazza N, Delgado ME, Schnalzger T, Schoonjans K, Brunner T
Science Advances 2019;5:eaav9732
The many faces of tumor necrosis factor signaling in the intestinal epithelium
Delgado ME*, Brunner T (*corresponding author)
Genes Immunology 2019;20:609
Inhibitor of apoptosis protein-1 regulates tumor necrosis factor-mediated destruction of intestinal epithelial cells
Grabinger T, Bode KJ, Demgenski J, Seitz C, Delgado ME, Kostadinova F, Reinhold C, Etemadi N, Wilhelm S, Schweinlin M, Hänggi K, Knop J, Hauck C, Walles H, Silke J, Wajant H, Nachbur U, W Wei-Lynn W, Brunner T
Gastroenterology 2017;152:867
Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions
Schwaderer J, Gaiser AK, Phan TS, Delgado ME, Brunner T
Cell Death & Disease 2017;8:e2745
Cell death at the intestinal epithelial front line
Delgado ME, Grabinger T, Brunner T
FEBS Journal 2016;283:2701
An analysis of the truncated Bid- and ROS-dependent spatial propagation of mitochondrial permeabilization waves during apoptosis
Jacob SF, Würstle ML, Delgado ME, Rehm M
Journal of Biological Chemistry 2016;26;291:4603
Analysis of cell death induction in intestinal organoids in vitro
Grabinger T, Delgado E, Brunner T
Methods in Molecular Biology 2016;1419:83
Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death
Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SWG
Molecular Cell 2015;57:860
Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways
Delgado ME, Dyck L, Laussmann MA, Rehm M
Cell Death & Disease 2014;5:e1011
Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution
Delgado ME, Olsson M, Lincoln FA, Zhivotovsky B, Rehm M
Biochimica et Biophysica Acta 2013;1833:2279
Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8
Laussmann MA, Passante E, Dussmann H, Rauen JA, Würstle ML, Delgado ME, Devocelle M, Prehn JH, Rehm M
Cell Death & Differentiation 2011;18:1584
Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilisation
Flanagan L, Sebastia J, Delgado ME, Lennon JC, Rehm M
Biochimica et Biophysica Acta 2011;1813:819
Myricetin, quercetin, (+)-catechin and (-)-epicatechin protect against N-nitrosamines-induced DNA damage in human hepatoma cells
Delgado ME, Haza AI, Garcia A, Morales P
Toxicology In Vitro 2009;23:1292
Antiapoptotic effects of dietary antioxidants towards N-nitrosopiperidine and N-nitrosodibutylamine-induced apoptosis in HL-60 and HepG2 cells
Garcia A, Morales P, Arranz N, Delgado ME, Rafter J, Haza AI
Journal of Applied Toxicology 2009;29:403
Dietary polyphenols protect against N-nitrosamines and benzo(a)pyrene-induced DNA damage (strand breaks and oxidized purines/pyrimidines) in HepG2 human hepatoma cells
Delgado ME, Haza AI, Arranz N, Garcia A, Morales P
European Journal of Nutrition 2008;47:479
Inhibition by vitamin C of apoptosis induced by N-nitrosamines in HepG2 and HL-60 cells
Arranz N, Haza AI, Garcia A, Delgado ME, Rafter J, Morales P
Journal of Applied Toxicology 2008;28:788
Organosulfur compounds alone or in combination with vitamin C protect towards N-nitrosopiperidine- and N-nitrosodibutylamine-induced oxidative DNA damage in HepG2 cells
Garcia A, Haza AI, Arranz N, Delgado ME, Rafter J, Morales P
Chemico-Biological Interactions 2008;173:9
Induction of apoptosis and reactive oxygen species production by N-nitrosopiperidine and N-nitrosodibutylamine in human leukemia cells
Garcia A, Morales P, Arranz N, Delgado E, Rafter J, Haza AI
Journal of Applied Toxicology 2008;28:455
Effect of pH on the antimicrobial activity and oxidative stability of oil-in-water emulsions containing caffeic acid
Almajano MP, Carbo R, Delgado ME, Gordon MH
Journal of Food Science 2007;72:C258
Effects of organosulfurs, isothiocyanates and vitamin C towards hydrogen peroxide-induced oxidative DNA damage (strand breaks and oxidized purines/pyrimidines) in human hepatoma cells
Arranz N, Haza AI, Garcia A, Delgado E, Rafter J, Morales P
Chemico-Biological Interactions 2007;169:63
Albumin causes a synergistic increase in the antioxidant activity of green tea catechins in oli-in-water emulsions
Almajano MP, Delgado ME, Gordon MH
Food Chemistry 2007;102:1375-1382
Changes in the antioxidant properties of protein solutions in the presence of epigallocatechin gallate
Almajano MP, Delgado ME, Gordon MH
Food Chemistry 2006; 101:126-130