Ester Garcia-Pras

 

Contact: egpras@clinic.cat

Academic Role: Postdoctoral Researcher

Biography: Ester Garcia-Pras (Granollers, Barcelona, 1978) earned her Bachelor’s of Science degree in Biology from the University of Barcelona in 2001, her Master of Science in Microbiology from the University Institute of Science and Technology (IUCT, Barcelona) in 2003, her Master of Science in Liver Disease from the University of Barcelona in 2011, and her PhD degree in Biology  from the University of Barcelona in 2018. She conducted predoctoral research at the Oncology Research Institute of Barcelona (2000-2001), the Experimental Cardiology Laboratory at the IDIBAPS (2003-2006), the Fecunmed Assisted Reproduction Laboratory (Barcelona) (2002), the Microbiology Department at Bioquim S.A. (Barcelona) (2003), and the Animal Health Research Center (CRESA, Barcelona) (2006). She has also earned the professional Certificate in Radioactive Installations Supervision (2006), the Certificate in Training on Experimental Animal Use and Design of Research Projects of the University of Barcelona (2006), the Certificate in Processing and Image Analysis in Advanced Microscopy with ImageJ from the University of Barcelona (2012), and the Certificate in Introduction to Flow Cytometry from IDIBAPS (2016), and participates in the oficial IDIBAPS Training Programme for Pre and Postdoctoral Researchers (from 2016). In October 2018, Ester co-organized and co-presented the Workshop in Vascular Biology Techniques during the European Club for Liver Cell Biology meeting (Bonn, Germany). She also participated as a Faculty Member in the Basic School of Hepatology of the European Association for the Study of Liver (Barcelona, October 2018). Ester joined the Mercedes Fernandez Lab in  November 2006.

Publications

Molecular and cellular mechanisms of neovascularization in portal hypertension and cirrhosis

Garcia-Pras E

Doctoral Thesis – University of Barcelona (2018)

Ductular reaction cells promote angiogenesis via SLIT2/ROBO1 pathway in chronic liver disease

Coll M, Garcia-Pras E, Aguilar-Bravo B, Gallego J, Blaya D, Vallverdu J, Perea L, Graupera I, Pose E, Lozano J, Bataller R, Gines P, Geng JG, Fernandez M, Sancho-Bru P

Journal of Hepatology (2018); 68: S92

This abstract has been presented as Oral Communication at the Liver Meeting of the European Association for the Study of the Liver (EASL) (Paris, France, 2018).  

Therapeutic siRNA targeting endothelial KDR decreases portosystemic collateralization in portal hypertension

Gallego J, Garcia-Pras E, Mejias M, Pell N, Schaeper U, Fernandez M

Co-first authors: Javier Gallego and Ester Garcia-Pras

Corresponding author: Mercedes Fernandez

Scientific Reports (2017) 7:14791-14806  PubMed    Springer Nature SharedIt

Gene therapy with endothelial-specific liposomal short interfering siRNA targeting kinase insert domain receptor inhibits portosystemic collateralization in portal hypertension

Gallego J, Garcia-Pras E, Mejias M, Pell N, Schaeper U, Fernandez M

Corresponding author: Mercedes Fernandez

Hepatology (2017); 66(1) (Suppl.): 141A

This abstract has been presented in Parallel Session at the Liver Meeting of the American Association for the Study of Liver Disease (AASLD) (Washington DC, 2017). The speaker and coauthor, Nuria Pell, has been awarded with the 2017 Basic Science Young Investigator Travel Award from AASLD, which recognizes outstanding young basic science researchers working on liver disease. 

Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension

Garcia-Pras E, Gallego J, Coch L, Mejias M, Fernandez-Miranda G, Pardal R, Bosch J, Mendez R, Fernandez M

Corresponding author: Mercedes Fernandez

Gut (2017) 66:1306-1320

Sequential functions of CPEB1 and CPEB4 regulate pathologic expression of VEGF and angiogenesis in chronic liver disease

Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R

Co-first authors: Javier Gallego and Vittorio Calderone

Corresponding author: Raul Mendez and Mercedes Fernandez

Gastroenterology (2016) 150:982-997

Pathogenesis of portal hypertension: Extrahepatic mechanisms

Fernandez M, Mejias M, Garcia-Pras E, Gallego J, Pell N, Ramirez M, Naranjo-Suarez S, Barrachina-Catala A

Corresponding author: Mercedes Fernandez

Current Hepatology Reports (2016) 15:199-207

Invited Review

Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats

Mejias M, Coch L, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Gut (2015) 64:657-666

Editorial devoted to this article: Vespasiani-Gentilucci U, Rombouts K. Boosting pigment epithelial-derived factor: a promising approach for the treatment of early portal hypertension. Gut (2015) 64:523-524 

Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats

Coch L, Mejias M, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, Mendez R, Fernandez M

Corresponding author: Mercedes Fernandez

Hepatology (2014) 60:633-647

Editorial devoted to this article: Chatterjee S. Reversal of vasohibin-driven negative feedback loop of vascular endothelial growth factor/angiogenesis axis promises a novel antifibrotic therapeutic strategy for liver diseases. Hepatology (2014) 60:458-460 

Hepatology Highlights devoted to this article: Dufour JF. After vasopressin comes vasohibin. Hepatology (2014) 60:447 

Effects of the combined administration of propranolol plus sorafenib on portal hypertension in cirrhotic rats

D’Amico M, Mejias M, Garcia-Pras E, Abraldes JG, Garcia-Pagan JC, Fernandez M, Bosch J

American Journal of Physiology (2012) 302:G1191-G1198

Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension

Mejias M, Garcia-Pras E, Gallego J, Mendez R, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2010) 52:529-539

Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats

Mejias M, Garcia-Pras E, Tiani C, Miquel R, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Hepatology (2009) 49:1245-1256

Editorial devoted to this article: Shah VH, Bruix J. Antiangiogenic therapy: not just for cancer anymore? Hepatology (2009) 49:1066-1068

Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension

Tiani C, Garcia-Pras E, Mejias M, de Gottardi A, Berzigotti A, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Hepatology (2009) 50:296-305

Decreased expression of thrombospondin-1 in failing hearts may favor ventricular remodeling

Batlle M, Perez-Villa F, Lazaro A, Garcia-Pras E, Vallejos I, Sionis A, Castel MA, Roig E

Transplantation Proceedings (2009) 41:2231-2233

The somatostatin analogue octreotide inhibits angiogenesis in the earliest, but not in advanced, stages of portal hypertension in rats

Mejias M, Garcia-Pras E, Tiani C, Bosch J, Fernandez M

Corresponding author: Mercedes Fernandez

Journal of Cellular and Molecular Medicine (2008) 12:1690-1699

Role of angiogenesis in portal hypertension

Fernandez M, Mejias M, Garcia-Pras E, Bosch J

Corresponding author: Mercedes Fernandez

In: Proceedings of the II Falk Gastro-Conference (2008) Ed. Springuer, Dordrecht, The Netherlands, pages 112-129

Invited Review

Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats

Fernandez M, Mejias M, Garcia-Pras E, Mendez R, Garcia-Pagan JC, Bosch J

Corresponding author: Mercedes Fernandez

Hepatology (2007) 46:1208-1217

This paper received the Award to the Best Publication in Hepatology Research (Year 2007), from the Spanish Association for the Study of the Liver

Correlation between mast cell density and myocardial fibrosis in congestive heart failure patients

Batlle M, Perez-Villa F, Lazaro A, Garcia-Pras E, Ramirez J, Ortiz J, Orus J, Roque M, Heras M, Roig E

Transplantation Proceedings (2007) 39:2347-2349

Down-regulation of matrix metalloproteinase-9 (MMP-9) expression in the myocardium of congestive heart failure patients

Batlle M, Perez-Villa F, Garcia-Pras E, Lazaro A, Orus J, Roque M, Roig E

Transplantation Proceeding (2007) 39:2344-2346

Increased expression of the renin-angiotensin system and mast cell density but not of angiotensin-converting enzyme II in late stages of human heart failure

Batlle M, Roig E, Perez-Villa F, Lario S, Cejudo-Martin P, Garcia-Pras E, Ortiz J, Roque M, Orus J, Rigol M, Heras M, Ramirez J, Jimenez W

Journal of Heart and Lung Transplantation (2006) 25:1117-1125

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