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Labs

Mercedes Fernandez Lab

 

Understanding the causes and drivers of liver disease to improve human health

I

The Mercedes Fernandez Lab is part of the IDIBAPS Biomedical Research Institute (Barcelona, Spain), composed by the Hospital Clinic of Barcelona and the Faculty of Medicine University of Barcelona, and is also affiliated to the Spanish Biomedical Research Networking Center on Hepatic and Digestive Disease (CIBEREHD). Our research focuses on identifying the causes and drivers of chronic liver diseases, including cirrhosis of the liver and liver cancer, which affect millions of humans beings and are leading causes of death and liver transplantation worldwide. This is essential to fully elucidate unresolved pathogenetic mechanisms, discover new drug targets, and facilitate the identification of novel therapeutic avenues that may be used to prevent or treat liver diseases. The hope being to eventually have an impact on clinical care and reduce the morbility and mortality of patients suffering from chronic liver disease.

The major aims of our team are:

  • To understand the function and regulation/dysregulation of angiogenesis in chronic liver disease.

  • To explore the pathogenic mechanisms underpinning the detrimental impact of obesity on chronic liver disease.

  • To decipher the major disease-relevant pathways in the progression from liver steatosis to fibrosis and liver cancer.

  • To apply our knowledge and research discoveries on the fundamental cell biology/pathophysiology of liver disease to the comprehension, prevention or treatment of human pathologies.

To achieve these goals, we take a multidisciplinary approach that employs in vivo studies in animal models of liver disease and genetically engineered mouse models, cellular and molecular biology analyses, biochemistry techniques, strategies in primary cell cultures and established mammalian cell lines and human tissues, to systematically dissect the pathologic signaling pathways of interest which could be therapeutically targeted to improve human health.

Please contact us for any questions or for more information about our lab at: mercefernandez@ub.edu

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